Medically Reviewed and Compiled by Dr. Adam N. Khan, MD.

Measles Outbreak South Carolina: Everything You Need to Know

Quick Answer: As of early 2026, South Carolina is facing its largest measles outbreak in decades, with 847 confirmed cases centered primarily in Spartanburg County. This measles outbreak South Carolina began in October 2025 and has spread rapidly due to declining vaccination rates in the Upstate region. Health officials are urging residents to check their immunization records through the SIMON portal and ensure children have received both doses of the MMR vaccine.

The Current State of the Measles Outbreak in South Carolina

The situation in the Palmetto State has reached a critical point. What started as a handful of travel-related cases in late 2025 has snowballed into a major public health emergency. According to the South Carolina Department of Public Health (DPH), the case count recently surpassed 800, making it the most significant surge in the United States so far this year.

Where is the Outbreak Happening?

The epicenter of the crisis is Spartanburg County. While cases have appeared in other Upstate counties like Greenville, the majority of infections are concentrated in Spartanburg. Exposure sites have included:

Local elementary and high schools.
Public restaurants, including high-traffic fast-food locations.
Places of worship, such as several local churches in the Spartanburg area.

Health officials have warned that the virus is now circulating through community spread. This means people are catching the virus in public spaces even if they haven’t knowingly been near a sick person.

Why is Measles Spreading So Fast in the Upstate?

Measles is one of the most contagious viruses known to man. If one person has it, up to 9 out of 10 people nearby will catch it if they aren’t immune. In South Carolina, two main factors are fueling the fire:

Low Vaccination Rates: To stop measles, about 95% of the community needs to be vaccinated. In Spartanburg County, some school rates have dipped to 90%, and some specific charter schools have reported rates as low as 21%.
Increased Exemptions: The Washington Post reports that religious exemptions for childhood vaccines in Spartanburg County have more than tripled over the last few years. This has created “pockets” of unprotected people where the virus can jump easily from person to person.

Identifying Symptoms: What to Look For

Measles doesn’t just start with a rash. It begins like a bad cold. If you live in South Carolina, watch for these signs:

The First Phase (Days 1–4): High fever, cough, runny nose, and red, watery eyes.
The Mouth Spots: Small white spots (called Koplik spots) may appear inside the mouth a few days before the rash.
The Rash (Days 3–5): A red, blotchy rash that usually starts on the face at the hairline and spreads downward to the neck, trunk, and legs.

If you suspect you or your child has measles, do not walk into a doctor’s office or ER. Call ahead first. The virus can stay in the air for up to two hours after a sick person leaves a room. Doctors need to prepare a private entrance to keep others safe.

How to Protect Your Family During the Outbreak

The best defense is the MMR (Measles, Mumps, and Rubella) vaccine. It is 97% effective after two doses.

Vaccination Guidelines for South Carolinians

Standard Schedule: The first dose is given at 12–15 months and the second at 4–6 years.
Outbreak Guidance: If you live in an outbreak area, the CDC suggests infants as young as 6 months can get an early dose for protection.
Cost and Access: The South Carolina DPH is running Mobile Health Units in the Upstate to provide free vaccines. You can also find them at local pharmacies and your family doctor.

What if You Were Exposed?

If you find out you were at an exposure site, you have a small window to act. Getting the vaccine within 72 hours of exposure can often prevent the disease or make it much milder. If it has been more than three days, a doctor might suggest a “protective shot” called immunoglobulin within 6 days.

Treatment and Recovery

There is no specific “cure” for measles; medical professionals focus on managing symptoms while the body’s immune system fights the virus. Key aspects of care include:

Rest and Fluids: Maintaining adequate hydration is crucial, especially with fever.
Vitamin A: The World Health Organization suggests Vitamin A supplementation for children with measles, as it may help prevent severe complications, including eye damage.
Isolation: To prevent further spread, individuals diagnosed with measles must remain isolated from others. Health guidelines typically recommend isolation for a specific period after the rash appears.

Why This Outbreak Matters Nationally

The current situation in South Carolina is drawing attention from public health experts across the United States. Organizations like NPR and national health agencies are expressing concern that sustained outbreaks could jeopardize the country’s “measles eliminated” status. This designation means that measles is not constantly circulating within the U.S. population. Prolonged outbreaks could lead to this status being revoked, increasing the risk of wider spread.

Summary of Key Takeaways

Total Cases: As of late January 2026, South Carolina has reported over 840 cases.
Hotspot: The majority of cases are concentrated in Spartanburg County and the surrounding Upstate region.
Who is at Risk: Individuals who are not vaccinated, including infants under 12 months old, are most vulnerable.
Action Step: Residents are encouraged to verify their vaccination status via the SIMON immunization portal or contact their pediatrician.

Medical Disclaimer

All content published on medlifeguide is intended for informational and educational purposes only and does not substitute professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider regarding any medical condition, symptoms, or treatment decisions.